MYELOID NEOPLASIA Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations
نویسندگان
چکیده
Britta Will,1 Li Zhou,1 Thomas O. Vogler,1 Susanna Ben-Neriah,2 Carolina Schinke,1 Roni Tamari,1 Yiting Yu,1 Tushar D. Bhagat,1 Sanchari Bhattacharyya,1 Laura Barreyro,1 Christoph Heuck,1 Yonkai Mo,1 Samir Parekh,1 Christine McMahon,1 Andrea Pellagatti,3 Jacqueline Boultwood,3 Cristina Montagna,1 Lewis Silverman,4 Jaroslaw Maciejewski,5 John M. Greally,1 B. Hilda Ye,1 Alan F. List,6 Christian Steidl,2 Ulrich Steidl,1 and Amit Verma1
منابع مشابه
Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations.
Even though hematopoietic stem cell (HSC) dysfunction is presumed in myelodysplastic syndrome (MDS), the exact nature of quantitative and qualitative alterations is unknown. We conducted a study of phenotypic and molecular alterations in highly fractionated stem and progenitor populations in a variety of MDS subtypes. We observed an expansion of the phenotypically primitive long-term HSCs (line...
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As hematopoietic cells proceed in differentiation from stem cells to committed progenitors to later stage mature forms, they undergo a sequence of morphologic, immunophenotypic, and functional changes that are a consequence of interaction between the underlying cellular genetic program and environmental cues, are linear for each cell lineage, and result in a pattern of antigenic expression rela...
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Chromosomal instability (CIN) is a characteristic feature of cancer. In this review, we concentrate on mechanisms leading to CIN in myeloid neoplasia, i.e., myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The pathogenesis of myeloid neoplasia is complex and involves genetic and epigenetic alterations. Chromosome aberrations define specific subgroups and guide clinical decisions....
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تاریخ انتشار 2012